BDBM124600 US8759532, 284

SMILES: O=C1CC[C@H](C1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1

InChI Key: InChIKey=BTRKUPPYXBYVGG-OAHLLOKOSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124600   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM124600 (US8759532, 284) Show SMILES O=C1CC[C@H](C1)c1cccnc1Oc1ccc(Nc2nc3ccccc3s2)cc1 |r| Show InChI InChI=1S/C23H19N3O2S/c27-17-10-7-15(14-17)19-4-3-13-24-22(19)28-18-11-8-16(9-12-18)25-23-26-20-5-1-2-6-21(20)29-23/h1-6,8-9,11-13,15H,7,10,14H2,(H,25,26)/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.169	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description To check the inhibition profile, 5 μL of serial diluted compounds were incubated with 5 μL of diluted PDE10 enzyme (BPS Bioscience, San Die...				US Patent US8759532 (2014) BindingDB Entry DOI: 10.7270/Q25D8QHR
					More data for this Ligand-Target Pair