null

SMILES: Cc1c(nc2cc(F)cc(F)c2c1N1CC(C)(C)c2ncc(cc12)N1CCOCC1)N1CCOC(C)(C)C1

InChI Key: InChIKey=FKBIGKZFSSEDIY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124764   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM124764 (US8765940, 2-(2,2-dimethyl-4-morpholinyl)-4-(3,3-d...) Show SMILES Cc1c(nc2cc(F)cc(F)c2c1N1CC(C)(C)c2ncc(cc12)N1CCOCC1)N1CCOC(C)(C)C1 Show InChI InChI=1S/C29H35F2N5O2/c1-18-25(36-16-28(2,3)26-23(36)14-20(15-32-26)34-6-9-37-10-7-34)24-21(31)12-19(30)13-22(24)33-27(18)35-8-11-38-29(4,5)17-35/h12-15H,6-11,16-17H2,1-5H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.52	n/a	n/a	n/a	n/a	n/a	n/a	7.0	n/a
Amgen Inc. US Patent					Assay Description A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...				US Patent US8765940 (2014) BindingDB Entry DOI: 10.7270/Q2WW7G94
					More data for this Ligand-Target Pair