BDBM124784 US8765940, 1'-(2-(3-fluorophenyl)-3-methyl-1,8-naphthyridin-4-yl)-6'-(4-morpholinyl)-1',2,2',3,5,6-hexahydrospiro[pyran-4,3'-pyrrolo[3,2-b]pyridine]

SMILES: Cc1c(nc2ncccc2c1N1CC2(CCOCC2)c2ncc(cc12)N1CCOCC1)-c1cccc(F)c1

InChI Key: InChIKey=PXKHCPJABXRWOX-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 124784   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM124784 (US8765940, 1'-(2-(3-fluorophenyl)-3-methyl-1,8...) Show SMILES Cc1c(nc2ncccc2c1N1CC2(CCOCC2)c2ncc(cc12)N1CCOCC1)-c1cccc(F)c1 Show InChI InChI=1S/C30H30FN5O2/c1-20-26(21-4-2-5-22(31)16-21)34-29-24(6-3-9-32-29)27(20)36-19-30(7-12-37-13-8-30)28-25(36)17-23(18-33-28)35-10-14-38-15-11-35/h2-6,9,16-18H,7-8,10-15,19H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	5.38	n/a	n/a	n/a	n/a	n/a	n/a	7.0	n/a
Amgen Inc. US Patent					Assay Description A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...				US Patent US8765940 (2014) BindingDB Entry DOI: 10.7270/Q2WW7G94
					More data for this Ligand-Target Pair