BDBM125020 US8772510, 39

SMILES: Cc1oc(nc1CCNC(=O)c1c(cnn1C)C(=O)N1CC(F)C1)-c1ccccc1

InChI Key: InChIKey=HPVYIJOYZBPZQT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 125020   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM125020 (US8772510, 39) Show SMILES Cc1oc(nc1CCNC(=O)c1c(cnn1C)C(=O)N1CC(F)C1)-c1ccccc1 Show InChI InChI=1S/C21H22FN5O3/c1-13-17(25-20(30-13)14-6-4-3-5-7-14)8-9-23-19(28)18-16(10-24-26(18)2)21(29)27-11-15(22)12-27/h3-7,10,15H,8-9,11-12H2,1-2H3,(H,23,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18.5	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description PDE10 activity of the compounds of the present invention was determined using a Scintillation Proximity Assay (SPA)-based method similar to the one p...				US Patent US8772510 (2014) BindingDB Entry DOI: 10.7270/Q2MG7N67
					More data for this Ligand-Target Pair