BDBM127665 US8791123, 38

SMILES: CC(C)(NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1F)C#N

InChI Key: InChIKey=DGJFIALUJKAIAO-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 127665   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127665 (US8791123, 38) Show SMILES CC(C)(NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1F)C#N Show InChI InChI=1S/C21H20F2N6O/c1-21(2,12-24)27-20(30)15-11-25-29-9-7-18(26-19(15)29)28-8-3-4-17(28)14-10-13(22)5-6-16(14)23/h5-7,9-11,17H,3-4,8H2,1-2H3,(H,27,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127665 (US8791123, 38) Show SMILES CC(C)(NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cc(F)ccc1F)C#N Show InChI InChI=1S/C21H20F2N6O/c1-21(2,12-24)27-20(30)15-11-25-29-9-7-18(26-19(15)29)28-8-3-4-17(28)14-10-13(22)5-6-16(14)23/h5-7,9-11,17H,3-4,8H2,1-2H3,(H,27,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.5	n/a
Array Biopharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair