BDBM127706 US8791123, 79

SMILES: OCc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1

InChI Key: InChIKey=JCTABYLGPPBJQB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 127706   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127706 (US8791123, 79) Show SMILES OCc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1 Show InChI InChI=1S/C20H21FN6O2/c21-12-8-14(16(11-28)22-9-12)17-2-1-6-26(17)18-5-7-27-19(25-18)15(10-23-27)20(29)24-13-3-4-13/h5,7-10,13,17,28H,1-4,6,11H2,(H,24,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	698	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127706 (US8791123, 79) Show SMILES OCc1ncc(F)cc1C1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1 Show InChI InChI=1S/C20H21FN6O2/c21-12-8-14(16(11-28)22-9-12)17-2-1-6-26(17)18-5-7-27-19(25-18)15(10-23-27)20(29)24-13-3-4-13/h5,7-10,13,17,28H,1-4,6,11H2,(H,24,29)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.5	n/a
Array Biopharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair