null

SMILES: O[C@H]1CCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1

InChI Key: InChIKey=RKRWQXHCILAOQU-KURKYZTESA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 127762   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127762 (US10758542, Example 135 | US8791123, 135 | US97824...) Show SMILES O[C@H]1CCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r| Show InChI InChI=1S/C21H23FN6O2/c22-14-9-13(10-23-11-14)17-4-2-7-27(17)19-6-8-28-20(26-19)15(12-24-28)21(30)25-16-3-1-5-18(16)29/h6,8-12,16-18,29H,1-5,7H2,(H,25,30)/t16-,17-,18+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	142	n/a	n/a	n/a	n/a	7.5	n/a
Array Biopharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127762 (US10758542, Example 135 | US8791123, 135 | US97824...) Show SMILES O[C@H]1CCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r| Show InChI InChI=1S/C21H23FN6O2/c22-14-9-13(10-23-11-14)17-4-2-7-27(17)19-6-8-28-20(26-19)15(12-24-28)21(30)25-16-3-1-5-18(16)29/h6,8-12,16-18,29H,1-5,7H2,(H,25,30)/t16-,17-,18+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127762 (US10758542, Example 135 | US8791123, 135 | US97824...) Show SMILES O[C@H]1CCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r| Show InChI InChI=1S/C21H23FN6O2/c22-14-9-13(10-23-11-14)17-4-2-7-27(17)19-6-8-28-20(26-19)15(12-24-28)21(30)25-16-3-1-5-18(16)29/h6,8-12,16-18,29H,1-5,7H2,(H,25,30)/t16-,17-,18+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	142	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM127762 (US10758542, Example 135 | US8791123, 135 | US97824...) Show SMILES O[C@H]1CCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r| Show InChI InChI=1S/C21H23FN6O2/c22-14-9-13(10-23-11-14)17-4-2-7-27(17)19-6-8-28-20(26-19)15(12-24-28)21(30)25-16-3-1-5-18(16)29/h6,8-12,16-18,29H,1-5,7H2,(H,25,30)/t16-,17-,18+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Jak2: Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mix...				US Patent US10758542 (2020)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127762 (US10758542, Example 135 | US8791123, 135 | US97824...) Show SMILES O[C@H]1CCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r| Show InChI InChI=1S/C21H23FN6O2/c22-14-9-13(10-23-11-14)17-4-2-7-27(17)19-6-8-28-20(26-19)15(12-24-28)21(30)25-16-3-1-5-18(16)29/h6,8-12,16-18,29H,1-5,7H2,(H,25,30)/t16-,17-,18+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	142	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Homo sapiens (Human))	BDBM127762 (US10758542, Example 135 | US8791123, 135 | US97824...) Show SMILES O[C@H]1CCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r| Show InChI InChI=1S/C21H23FN6O2/c22-14-9-13(10-23-11-14)17-4-2-7-27(17)19-6-8-28-20(26-19)15(12-24-28)21(30)25-16-3-1-5-18(16)29/h6,8-12,16-18,29H,1-5,7H2,(H,25,30)/t16-,17-,18+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127762 (US10758542, Example 135 | US8791123, 135 | US97824...) Show SMILES O[C@H]1CCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r| Show InChI InChI=1S/C21H23FN6O2/c22-14-9-13(10-23-11-14)17-4-2-7-27(17)19-6-8-28-20(26-19)15(12-24-28)21(30)25-16-3-1-5-18(16)29/h6,8-12,16-18,29H,1-5,7H2,(H,25,30)/t16-,17-,18+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	142	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10758542 (2020)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127762 (US10758542, Example 135 | US8791123, 135 | US97824...) Show SMILES O[C@H]1CCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1 |r| Show InChI InChI=1S/C21H23FN6O2/c22-14-9-13(10-23-11-14)17-4-2-7-27(17)19-6-8-28-20(26-19)15(12-24-28)21(30)25-16-3-1-5-18(16)29/h6,8-12,16-18,29H,1-5,7H2,(H,25,30)/t16-,17-,18+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair