BDBM127873 US8791130, 3

SMILES: CNc1nc(Nc2ccc(cc2Cl)-c2nnn(C)n2)ncc1C(F)(F)F

InChI Key: InChIKey=JTGZONZBOKLQNN-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 127873   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM127873 (US8791130, 3) Show SMILES CNc1nc(Nc2ccc(cc2Cl)-c2nnn(C)n2)ncc1C(F)(F)F Show InChI InChI=1S/C14H12ClF3N8/c1-19-12-8(14(16,17)18)6-20-13(22-12)21-10-4-3-7(5-9(10)15)11-23-25-26(2)24-11/h3-6H,1-2H3,(H2,19,20,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...				US Patent US8791130 (2014) BindingDB Entry DOI: 10.7270/Q2K9367R
					More data for this Ligand-Target Pair