BDBM127899 US8791130, 29

SMILES: CCNc1nc(Nc2cc(F)c(cc2OC)-c2nnc(C)o2)ncc1C(F)(F)F

InChI Key: InChIKey=IRVAJQJHJHEDGG-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 127899   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM127899 (US8791130, 29) Show SMILES CCNc1nc(Nc2cc(F)c(cc2OC)-c2nnc(C)o2)ncc1C(F)(F)F Show InChI InChI=1S/C17H16F4N6O2/c1-4-22-14-10(17(19,20)21)7-23-16(25-14)24-12-6-11(18)9(5-13(12)28-3)15-27-26-8(2)29-15/h5-7H,4H2,1-3H3,(H2,22,23,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...				US Patent US8791130 (2014) BindingDB Entry DOI: 10.7270/Q2K9367R
					More data for this Ligand-Target Pair