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SMILES: CNc1nc(Nc2cc(F)c(cc2OC)-c2cnn(c2)C2COC2)ncc1C(F)(F)F

InChI Key: InChIKey=WVRKLDSCWQMVFE-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 127914   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM127914
PNG
(US8791130, 44)
Show SMILES CNc1nc(Nc2cc(F)c(cc2OC)-c2cnn(c2)C2COC2)ncc1C(F)(F)F
Show InChI InChI=1S/C19H18F4N6O2/c1-24-17-13(19(21,22)23)6-25-18(28-17)27-15-4-14(20)12(3-16(15)30-2)10-5-26-29(7-10)11-8-31-9-11/h3-7,11H,8-9H2,1-2H3,(H2,24,25,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
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PC cid
PC sid
UniChem
US Patent
 10n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...

US Patent US8791130 (2014)


BindingDB Entry DOI: 10.7270/Q2K9367R
More data for this
Ligand-Target Pair