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SMILES: CNc1nc(Nc2ccc(cc2OC)-n2nc(C)cc2COC)ncc1C(F)(F)F

InChI Key: InChIKey=QVAYMZPCDRJYKC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 127918   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM127918 (US8791130, 48) Show SMILES CNc1nc(Nc2ccc(cc2OC)-n2nc(C)cc2COC)ncc1C(F)(F)F Show InChI InChI=1S/C19H21F3N6O2/c1-11-7-13(10-29-3)28(27-11)12-5-6-15(16(8-12)30-4)25-18-24-9-14(19(20,21)22)17(23-2)26-18/h5-9H,10H2,1-4H3,(H2,23,24,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...				US Patent US8791130 (2014) BindingDB Entry DOI: 10.7270/Q2K9367R
					More data for this Ligand-Target Pair