BDBM127919 US8791130, 49

SMILES: CNc1nc(Nc2cc(F)c(cc2OC)-n2nnnc2COC)ncc1C(F)(F)F

InChI Key: InChIKey=CRWLKZVJTVGYSW-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 127919   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM127919 (US8791130, 49) Show SMILES CNc1nc(Nc2cc(F)c(cc2OC)-n2nnnc2COC)ncc1C(F)(F)F Show InChI InChI=1S/C16H16F4N8O2/c1-21-14-8(16(18,19)20)6-22-15(24-14)23-10-4-9(17)11(5-12(10)30-3)28-13(7-29-2)25-26-27-28/h4-6H,7H2,1-3H3,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...				US Patent US8791130 (2014) BindingDB Entry DOI: 10.7270/Q2K9367R
					More data for this Ligand-Target Pair