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SMILES: Cc1ccc(C)n2nc(CCc3cn4Cc5ccccc5-c4n3)nc12

InChI Key: InChIKey=KCEGJZKYKCTWDC-UHFFFAOYSA-N

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 127921   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM127921
PNG
(US8796304, 2-[2-(5,8-Dimethyl-[1,2,4]triazolo[1,5-...)
Show SMILES Cc1ccc(C)n2nc(CCc3cn4Cc5ccccc5-c4n3)nc12
Show InChI InChI=1S/C20H19N5/c1-13-7-8-14(2)25-19(13)22-18(23-25)10-9-16-12-24-11-15-5-3-4-6-17(15)20(24)21-16/h3-8,12H,9-11H2,1-2H3
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Similars
US Patent
n/an/a 0.690n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...

US Patent US8796304 (2014)


BindingDB Entry DOI: 10.7270/Q2FN14WW
More data for this
Ligand-Target Pair