BDBM128272 US8796296, 28

SMILES: CNc1nc(Nc2cc3n(C)cc(C(=O)N4CCNCC4)c3cc2Cl)ncc1C(F)(F)F

InChI Key: InChIKey=AZZINAZCKAUGNH-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 128272   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM128272 (US8796296, 28) Show SMILES CNc1nc(Nc2cc3n(C)cc(C(=O)N4CCNCC4)c3cc2Cl)ncc1C(F)(F)F Show InChI InChI=1S/C20H21ClF3N7O/c1-25-17-13(20(22,23)24)9-27-19(29-17)28-15-8-16-11(7-14(15)21)12(10-30(16)2)18(32)31-5-3-26-4-6-31/h7-10,26H,3-6H2,1-2H3,(H2,25,27,28,29)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US8796296 (2014) BindingDB Entry DOI: 10.7270/Q28W3C0R
					More data for this Ligand-Target Pair