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SMILES: COc1nc(ncc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(cc1)[N+]#[C-])c1cc(Cl)ccc1C)N(C)C

InChI Key: InChIKey=SLDHXOHIMFEVPD-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 129763   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM129763
PNG
(US8815926, 42)
Show SMILES COc1nc(ncc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(cc1)[N+]#[C-])c1cc(Cl)ccc1C)N(C)C
Show InChI InChI=1S/C29H28ClN7O2/c1-16(2)36-25-23(33-26(36)21-15-32-29(35(5)6)34-27(21)39-7)28(38)37(22-14-19(30)11-8-17(22)3)24(25)18-9-12-20(31-4)13-10-18/h8-16,24H,1-3,5-7H3
PDB
MMDB

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KEGG

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Similars
US Patent
n/an/a 0.110n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...

US Patent US8815926 (2014)


BindingDB Entry DOI: 10.7270/Q29P309G
More data for this
Ligand-Target Pair