BDBM129848 US8815926, 127

SMILES: COc1nc(ncc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cnc(O)c(Cl)c1)N(C)C

InChI Key: InChIKey=QZMKRXNCNGDXOD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 129848   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM129848 (US8815926, 127) Show SMILES COc1nc(ncc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cnc(O)c(Cl)c1)N(C)C Show InChI InChI=1S/C26H25Cl2N7O3/c1-13(2)34-21-19(31-22(34)17-12-30-26(33(3)4)32-24(17)38-5)25(37)35(16-10-18(28)23(36)29-11-16)20(21)14-6-8-15(27)9-7-14/h6-13,20H,1-5H3,(H,29,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G
					More data for this Ligand-Target Pair