BDBM130266 US8815840, 80

SMILES: CN1CCN(CC1)C(=O)c1ccc2c(c1)[nH]c1c(cc(cc21)-c1ccccc1)C(N)=O

InChI Key: InChIKey=AFGOHOKBWTUDJZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 130266   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM130266 (US8815840, 80) Show SMILES CN1CCN(CC1)C(=O)c1ccc2c(c1)[nH]c1c(cc(cc21)-c1ccccc1)C(N)=O Show InChI InChI=1S/C25H24N4O2/c1-28-9-11-29(12-10-28)25(31)17-7-8-19-20-13-18(16-5-3-2-4-6-16)14-21(24(26)30)23(20)27-22(19)15-17/h2-8,13-15,27H,9-12H2,1H3,(H2,26,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme and substrates (fluor...				US Patent US8815840 (2014) BindingDB Entry DOI: 10.7270/Q28P5Z65
					More data for this Ligand-Target Pair