BDBM130296 US8815840, 216

SMILES: NC(=O)c1cc(nc2c3ccc(cc3[nH]c12)C(=O)N1CCOCC1)-c1ccc(F)c(F)c1

InChI Key: InChIKey=CGAQZAYPPWLAFW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 130296   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM130296 (US8815840, 216) Show SMILES NC(=O)c1cc(nc2c3ccc(cc3[nH]c12)C(=O)N1CCOCC1)-c1ccc(F)c(F)c1 Show InChI InChI=1S/C23H18F2N4O3/c24-16-4-2-12(9-17(16)25)18-11-15(22(26)30)21-20(27-18)14-3-1-13(10-19(14)28-21)23(31)29-5-7-32-8-6-29/h1-4,9-11,28H,5-8H2,(H2,26,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme and substrates (fluor...				US Patent US8815840 (2014) BindingDB Entry DOI: 10.7270/Q28P5Z65
					More data for this Ligand-Target Pair