BDBM1303 3-Aminopyridin-2(1H)-one analogue 23::5-ethyl-3-[(1H-indol-3-ylmethyl)amino]-6-methyl-1,2-dihydropyridin-2-one::CHEMBL340255

SMILES: CCc1cc(NCc2c[nH]c3ccccc23)c(=O)[nH]c1C

InChI Key: InChIKey=IVYXCNFPTFUCEQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 1303   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM1303 (3-Aminopyridin-2(1H)-one analogue 23 | 5-ethyl-3-[...) Show SMILES CCc1cc(NCc2c[nH]c3ccccc23)c(=O)[nH]c1C Show InChI InChI=1S/C17H19N3O/c1-3-12-8-16(17(21)20-11(12)2)19-10-13-9-18-15-7-5-4-6-14(13)15/h4-9,18-19H,3,10H2,1-2H3,(H,20,21)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.24E+4	n/a	n/a	n/a	n/a	n/a	n/a
Organon Research Laboratories Curated by ChEMBL					Assay Description Inhibition of HIV-1 reverse transcriptase (HIV-1 RT)				J Med Chem 39: 4065-72 (1996) Article DOI: 10.1021/jm960058h BindingDB Entry DOI: 10.7270/Q2Z039F0
					More data for this Ligand-Target Pair
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1)	BDBM1303 (3-Aminopyridin-2(1H)-one analogue 23 | 5-ethyl-3-[...) Show SMILES CCc1cc(NCc2c[nH]c3ccccc23)c(=O)[nH]c1C Show InChI InChI=1S/C17H19N3O/c1-3-12-8-16(17(21)20-11(12)2)19-10-13-9-18-15-7-5-4-6-14(13)15/h4-9,18-19H,3,10H2,1-2H3,(H,20,21)	PDB MMDB B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.25E+4	n/a	n/a	n/a	n/a	8.2	n/a
Merck Research Laboratories					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 35: 3792-802 (1992) Article DOI: 10.1021/jm00099a007 BindingDB Entry DOI: 10.7270/Q2GH9G3P
					More data for this Ligand-Target Pair