BDBM130381 (R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)piperidin-4-yl]hexanoic acid (ABH-DP)
SMILES: N[C@](CCCCB(O)O)(C1CCN(Cc2ccc(Cl)c(Cl)c2)CC1)C(O)=O
InChI Key: InChIKey=RLPKENIQQACFGX-GOSISDBHSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Arginase-1 (Homo sapiens (Human)) | BDBM130381 ((R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)pipe...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc. Curated by ChEMBL | Assay Description Inhibition of human arginase1 in presence of DNTB by thio ornithine generation assay | ACS Med Chem Lett 11: 582-588 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Arginase (SmARG) (Schistosoma mansoni (flatworms)) | BDBM130381 ((R)-2-amino-6-borono-2-[1-(3,4-dichlorobenzyl)pipe...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 540 | n/a | n/a | n/a | 8.5 | n/a |
University of Pennsylvania | Assay Description SmARG was dialyzed against 50 mM bicine (pH 8.5), 100 μM MnCl2, and 1.0 mM TCEP [5% (v/v) DMSO was included in the dialysis buffer when SmARG wa... | Biochemistry 53: 4671-4684 (2014) Article DOI: 10.1021/bi5004519 BindingDB Entry DOI: 10.7270/Q2RR1WZQ | |||||||||||
More data for this Ligand-Target Pair |