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SMILES: Cc1cccc(c1C)-n1ncc2c1nc(CC1CCCC1)[nH]c2=O

InChI Key: InChIKey=PNJBMIFHRQDFQW-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 130498   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Homo sapiens (Human))		BDBM130498
PNG
(US8822479, 2)
Show SMILES Cc1cccc(c1C)-n1ncc2c1nc(CC1CCCC1)[nH]c2=O
Show InChI InChI=1S/C19H22N4O/c1-12-6-5-9-16(13(12)2)23-18-15(11-20-23)19(24)22-17(21-18)10-14-7-3-4-8-14/h5-6,9,11,14H,3-4,7-8,10H2,1-2H3,(H,21,22,24)
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Similars
US Patent
n/an/a 38n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. Typically, serial dilutions from 20...

US Patent US8822479 (2014)


BindingDB Entry DOI: 10.7270/Q2416VRP
More data for this
Ligand-Target Pair