BDBM130758 US8822448, 182

SMILES: C[C@@H]1CN(CCN1c1ccc(F)c(C)n1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)[C@H]1CCN(C)C1

InChI Key: InChIKey=LDJGXOYCLAYDMS-MJGOQNOKSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 130758   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 9 (PDE9) (Rattus norvegicus (Rat))	BDBM130758 (US8822448, 182) Show SMILES C[C@@H]1CN(CCN1c1ccc(F)c(C)n1)C(=O)c1cc2c3n(ncc3c(=O)[nH]c2cc1C)[C@H]1CCN(C)C1 |r| Show InChI InChI=1S/C28H32FN7O2/c1-16-11-24-21(26-22(27(37)32-24)13-30-36(26)19-7-8-33(4)15-19)12-20(16)28(38)34-9-10-35(17(2)14-34)25-6-5-23(29)18(3)31-25/h5-6,11-13,17,19H,7-10,14-15H2,1-4H3,(H,32,37)/t17-,19+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	8.0	n/a
Astellas Pharma Inc. US Patent					Assay Description The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...				US Patent US8822448 (2014) BindingDB Entry DOI: 10.7270/Q2BK1B1J
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