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SMILES: Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCN(CC(F)(F)F)CC1

InChI Key: InChIKey=QWFATCYZZRGFIU-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 130791   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A


(Rattus norvegicus (Rat))		BDBM130791
PNG
(US8822448, 427)
Show SMILES Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)N1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C23H26F3N5O3/c1-14-10-19-17(11-16(14)22(33)30-6-4-29(5-7-30)13-23(24,25)26)20-18(21(32)28-19)12-27-31(20)15-2-8-34-9-3-15/h10-12,15H,2-9,13H2,1H3,(H,28,32)
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MMDB

KEGG

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PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/a8.0n/a



Astellas Pharma Inc.

US Patent


Assay Description
The PDE9-inhibiting activity was measured by the following method. That is, to a buffer solution containing tris(hydroxymethyl)aminomethane-hydrochlo...

US Patent US8822448 (2014)


BindingDB Entry DOI: 10.7270/Q2BK1B1J
More data for this
Ligand-Target Pair