BDBM1308 2-pyridinone deriv. 26::3-Aminopyridin-2(1H)-one analogue 28::5-ethyl-6-methyl-3-[(pyridin-3-ylmethyl)amino]-1,2-dihydropyridin-2-one::CHEMBL85975

SMILES: CCc1cc(NCc2cccnc2)c(=O)[nH]c1C

InChI Key: InChIKey=PNCQHPWMBIIGAP-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 1308   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1)	BDBM1308 (2-pyridinone deriv. 26 | 3-Aminopyridin-2(1H)-one ...) Show SMILES CCc1cc(NCc2cccnc2)c(=O)[nH]c1C Show InChI InChI=1S/C14H17N3O/c1-3-12-7-13(14(18)17-10(12)2)16-9-11-5-4-6-15-8-11/h4-8,16H,3,9H2,1-2H3,(H,17,18)	PDB MMDB B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+5	n/a	n/a	n/a	n/a	8.2	n/a
Merck Research Laboratories					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 35: 3792-802 (1992) Article DOI: 10.1021/jm00099a007 BindingDB Entry DOI: 10.7270/Q2GH9G3P
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM1308 (2-pyridinone deriv. 26 | 3-Aminopyridin-2(1H)-one ...) Show SMILES CCc1cc(NCc2cccnc2)c(=O)[nH]c1C Show InChI InChI=1S/C14H17N3O/c1-3-12-7-13(14(18)17-10(12)2)16-9-11-5-4-6-15-8-11/h4-8,16H,3,9H2,1-2H3,(H,17,18)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.02E+5	n/a	n/a	n/a	n/a	n/a	n/a
Organon Research Laboratories Curated by ChEMBL					Assay Description Inhibition of HIV-1 reverse transcriptase (HIV-1 RT)				J Med Chem 39: 4065-72 (1996) Article DOI: 10.1021/jm960058h BindingDB Entry DOI: 10.7270/Q2Z039F0
					More data for this Ligand-Target Pair
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1)	BDBM1308 (2-pyridinone deriv. 26 | 3-Aminopyridin-2(1H)-one ...) Show SMILES CCc1cc(NCc2cccnc2)c(=O)[nH]c1C Show InChI InChI=1S/C14H17N3O/c1-3-12-7-13(14(18)17-10(12)2)16-9-11-5-4-6-15-8-11/h4-8,16H,3,9H2,1-2H3,(H,17,18)	PDB MMDB B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+5	n/a	n/a	n/a	n/a	8.2	n/a
Merck Research Laboratories					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 36: 249-55 (1993) Article DOI: 10.1021/jm00054a009 BindingDB Entry DOI: 10.7270/Q20863HM
					More data for this Ligand-Target Pair