BDBM130949 US8829190, 127

SMILES: COc1ccc(C(=O)Cc2ccccc2Cl)n2nc(nc12)C1CC1

InChI Key: InChIKey=HJESBHUKVRXBCT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 130949   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM130949 (US8829190, 127) Show SMILES COc1ccc(C(=O)Cc2ccccc2Cl)n2nc(nc12)C1CC1 Show InChI InChI=1S/C18H16ClN3O2/c1-24-16-9-8-14(15(23)10-12-4-2-3-5-13(12)19)22-18(16)20-17(21-22)11-6-7-11/h2-5,8-9,11H,6-7,10H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Leo Pharma A/S US Patent					Assay Description Human recombinant PDE4 (Gene bank accession no NM006203) was incubated for 1 hour with the test compound at concentrations up to 10 μM, with cAM...				US Patent US8829190 (2014) BindingDB Entry DOI: 10.7270/Q2Z89B3Z
					More data for this Ligand-Target Pair