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SMILES: COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1ccc2ccccc2n1

InChI Key: InChIKey=VFQQYQDWXYLYBQ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 13116   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Stromelysin-1


(Homo sapiens (Human))		BDBM13116
PNG
(CGS 27023A Analog 44 | N-hydroxy-2-[(4-methoxybenz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1ccc2ccccc2n1
Show InChI InChI=1S/C19H19N3O5S/c1-27-16-8-10-17(11-9-16)28(25,26)22(13-19(23)21-24)12-15-7-6-14-4-2-3-5-18(14)20-15/h2-11,24H,12-13H2,1H3,(H,21,23)
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 134n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...

J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair