BDBM131858 US8835444, 1.1

SMILES: CCc1[nH]nc(NC[C@H]2CC[C@@H](CC2)NC(=O)c2cc(Cl)cnc2C)c1C

InChI Key:

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 131858   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor 2 (Homo sapiens (Human))	BDBM131858 (US8835444, 1.1) Show SMILES CCc1[nH]nc(NC[C@H]2CC[C@@H](CC2)NC(=O)c2cc(Cl)cnc2C)c1C |r,wU:11.14,wD:8.7,(9.52,.08,;9.13,1.56,;7.64,1.96,;7.16,3.43,;5.62,3.43,;5.15,1.96,;3.81,1.19,;2.48,1.96,;1.15,1.19,;-.19,1.96,;-1.52,1.19,;-1.52,-.35,;-.19,-1.12,;1.15,-.35,;-2.86,-1.12,;-4.19,-.35,;-4.19,1.19,;-5.52,-1.12,;-6.86,-.35,;-8.19,-1.12,;-9.52,-.35,;-8.19,-2.66,;-6.86,-3.43,;-5.52,-2.66,;-4.19,-3.43,;6.39,1.06,;6.39,-.48,)| Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.88E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing either the human or rat recombinant CRF-1 or human CRF-2alpha (Chen et al, Proc Natl Acad Sci USA 90, 89...				US Patent US8835444 (2014) BindingDB Entry DOI: 10.7270/Q28K77ST
					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM131858 (US8835444, 1.1) Show SMILES CCc1[nH]nc(NC[C@H]2CC[C@@H](CC2)NC(=O)c2cc(Cl)cnc2C)c1C |r,wU:11.14,wD:8.7,(9.52,.08,;9.13,1.56,;7.64,1.96,;7.16,3.43,;5.62,3.43,;5.15,1.96,;3.81,1.19,;2.48,1.96,;1.15,1.19,;-.19,1.96,;-1.52,1.19,;-1.52,-.35,;-.19,-1.12,;1.15,-.35,;-2.86,-1.12,;-4.19,-.35,;-4.19,1.19,;-5.52,-1.12,;-6.86,-.35,;-8.19,-1.12,;-9.52,-.35,;-8.19,-2.66,;-6.86,-3.43,;-5.52,-2.66,;-4.19,-3.43,;6.39,1.06,;6.39,-.48,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	134	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing either the human or rat recombinant CRF-1 or human CRF-2alpha (Chen et al, Proc Natl Acad Sci USA 90, 89...				US Patent US8835444 (2014) BindingDB Entry DOI: 10.7270/Q28K77ST
					More data for this Ligand-Target Pair