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BDBM131861 US8835444, 2.0

SMILES: CCc1cc(CC)n(C[C@H]2CC[C@@H](CC2)NC(=O)c2cc(Cl)cnc2C)n1

InChI Key: InChIKey=YFGJKTCILASHFF-RZDIXWSQSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 131861   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM131861
PNG
(US8835444, 2.0)
Show SMILES CCc1cc(CC)n(C[C@H]2CC[C@@H](CC2)NC(=O)c2cc(Cl)cnc2C)n1 |r,wU:9.8,wD:12.15,(6.46,-3.52,;7.23,-2.19,;6.46,-.86,;7.36,.39,;6.46,1.64,;6.86,3.12,;8.34,3.52,;4.99,1.16,;3.66,1.93,;2.33,1.16,;2.33,-.38,;.99,-1.15,;-.34,-.38,;-.34,1.16,;.99,1.93,;-1.68,-1.15,;-3.01,-.38,;-3.01,1.16,;-4.34,-1.15,;-5.68,-.38,;-7.01,-1.15,;-8.34,-.38,;-7.01,-2.69,;-5.68,-3.46,;-4.34,-2.69,;-3.01,-3.46,;4.99,-.38,)|
Show InChI InChI=1S/C21H29ClN4O/c1-4-17-11-19(5-2)26(25-17)13-15-6-8-18(9-7-15)24-21(27)20-10-16(22)12-23-14(20)3/h10-12,15,18H,4-9,13H2,1-3H3,(H,24,27)/t15-,18-
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Similars
US Patent
n/an/a 160n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing either the human or rat recombinant CRF-1 or human CRF-2alpha (Chen et al, Proc Natl Acad Sci USA 90, 89...

US Patent US8835444 (2014)


BindingDB Entry DOI: 10.7270/Q28K77ST
More data for this
Ligand-Target Pair