BDBM131864 US8835444, 2.13

SMILES: Cc1cn(C[C@H]2CC[C@@H](CC2)NC(=O)c2cc(ccc2Cl)C(F)(F)F)nc1C

InChI Key: InChIKey=CYEKERUNBYWVCC-KOMQPUFPSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 131864   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM131864 (US8835444, 2.13) Show SMILES Cc1cn(C[C@H]2CC[C@@H](CC2)NC(=O)c2cc(ccc2Cl)C(F)(F)F)nc1C |r,wU:5.4,wD:8.11,(7.61,-1.42,;6.84,-.09,;5.38,.38,;5.38,1.93,;4.05,2.69,;2.71,1.93,;2.71,.38,;1.38,-.38,;.05,.38,;.05,1.93,;1.38,2.69,;-1.29,-.38,;-2.62,.38,;-2.62,1.93,;-3.96,-.38,;-5.29,.38,;-6.62,-.38,;-6.62,-1.93,;-5.29,-2.69,;-3.96,-1.93,;-2.62,-2.69,;-7.96,.38,;-9.29,-.38,;-7.96,1.93,;-9.29,1.15,;6.84,2.4,;7.75,1.15,;9.29,1.15,)| Show InChI InChI=1S/C20H23ClF3N3O/c1-12-10-27(26-13(12)2)11-14-3-6-16(7-4-14)25-19(28)17-9-15(20(22,23)24)5-8-18(17)21/h5,8-10,14,16H,3-4,6-7,11H2,1-2H3,(H,25,28)/t14-,16-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	167	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing either the human or rat recombinant CRF-1 or human CRF-2alpha (Chen et al, Proc Natl Acad Sci USA 90, 89...				US Patent US8835444 (2014) BindingDB Entry DOI: 10.7270/Q28K77ST
					More data for this Ligand-Target Pair