BDBM131866 US8835444, 2.15

SMILES: FC(F)(F)c1ccc(Cl)c(c1)C(=O)N[C@H]1CC[C@H](Cn2ncc3CCCc23)CC1

InChI Key: InChIKey=KAUBLHQZGOJOTO-SAZUREKKSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 131866   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM131866 (US8835444, 2.15) Show SMILES FC(F)(F)c1ccc(Cl)c(c1)C(=O)N[C@H]1CC[C@H](Cn2ncc3CCCc23)CC1 |r,wU:17.18,wD:14.14,(-8.58,-.45,;-7.25,.32,;-7.25,1.86,;-8.58,1.09,;-5.91,-.45,;-5.91,-1.99,;-4.58,-2.76,;-3.25,-1.99,;-1.91,-2.76,;-3.25,-.45,;-4.58,.32,;-1.91,.32,;-1.91,1.86,;-.58,-.45,;.75,.32,;2.09,-.45,;3.42,.32,;3.42,1.86,;4.76,2.63,;6.09,1.86,;7.34,2.76,;8.58,1.86,;8.11,.39,;8.58,-1.07,;7.34,-1.98,;6.09,-1.07,;6.57,.39,;2.09,2.63,;.75,1.86,)| Show InChI InChI=1S/C21H23ClF3N3O/c22-18-9-6-15(21(23,24)25)10-17(18)20(29)27-16-7-4-13(5-8-16)12-28-19-3-1-2-14(19)11-26-28/h6,9-11,13,16H,1-5,7-8,12H2,(H,27,29)/t13-,16-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing either the human or rat recombinant CRF-1 or human CRF-2alpha (Chen et al, Proc Natl Acad Sci USA 90, 89...				US Patent US8835444 (2014) BindingDB Entry DOI: 10.7270/Q28K77ST
					More data for this Ligand-Target Pair