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BDBM131867 US8835444, 2.16

SMILES: FC(F)(F)c1ccc(Cl)c(c1)C(=O)N[C@H]1CC[C@H](Cn2cc3CCCc3n2)CC1

InChI Key: InChIKey=NVMLZAHNDZRDTM-SAZUREKKSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 131867   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM131867
PNG
(US8835444, 2.16)
Show SMILES FC(F)(F)c1ccc(Cl)c(c1)C(=O)N[C@H]1CC[C@H](Cn2cc3CCCc3n2)CC1 |r,wU:17.18,wD:14.14,(-8.97,-.39,;-7.63,.38,;-7.63,1.92,;-8.97,1.15,;-6.3,-.39,;-6.3,-1.93,;-4.97,-2.7,;-3.63,-1.93,;-2.3,-2.7,;-3.63,-.39,;-4.97,.38,;-2.3,.38,;-2.3,1.92,;-.96,-.39,;.37,.38,;1.7,-.39,;3.04,.38,;3.04,1.92,;4.37,2.7,;5.7,1.92,;7.24,1.92,;7.72,.46,;8.97,-.44,;8.49,-1.91,;6.95,-1.91,;6.47,-.44,;5.23,.46,;1.7,2.7,;.37,1.92,)|
Show InChI InChI=1S/C21H23ClF3N3O/c22-18-9-6-15(21(23,24)25)10-17(18)20(29)26-16-7-4-13(5-8-16)11-28-12-14-2-1-3-19(14)27-28/h6,9-10,12-13,16H,1-5,7-8,11H2,(H,26,29)/t13-,16-
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Similars
US Patent
n/an/a 147n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing either the human or rat recombinant CRF-1 or human CRF-2alpha (Chen et al, Proc Natl Acad Sci USA 90, 89...

US Patent US8835444 (2014)


BindingDB Entry DOI: 10.7270/Q28K77ST
More data for this
Ligand-Target Pair