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BDBM131873 US8835444, 4.4

SMILES: Cc1cc(CO)n(C[C@H]2CC[C@@H](CC2)NC(=O)c2cc(Cl)cnc2C)n1

InChI Key: InChIKey=ACRFXQOGJGDSAR-KOMQPUFPSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 131873   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM131873
PNG
(US8835444, 4.4)
Show SMILES Cc1cc(CO)n(C[C@H]2CC[C@@H](CC2)NC(=O)c2cc(Cl)cnc2C)n1 |r,wU:8.7,wD:11.14,(8.63,1.15,;7.09,1.15,;6.19,-.09,;4.72,.38,;3.63,-.7,;4.03,-2.19,;4.71,1.93,;3.37,2.69,;2.04,1.93,;2.04,.38,;.7,-.38,;-.63,.38,;-.63,1.93,;.7,2.69,;-1.96,-.38,;-3.3,.38,;-3.3,1.93,;-4.63,-.38,;-5.96,.38,;-7.3,-.38,;-8.63,.38,;-7.3,-1.93,;-5.96,-2.69,;-4.63,-1.93,;-3.3,-2.69,;6.19,2.4,)|
Show InChI InChI=1S/C19H25ClN4O2/c1-12-7-17(11-25)24(23-12)10-14-3-5-16(6-4-14)22-19(26)18-8-15(20)9-21-13(18)2/h7-9,14,16,25H,3-6,10-11H2,1-2H3,(H,22,26)/t14-,16-
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Similars
US Patent
n/an/a 6.96E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing either the human or rat recombinant CRF-1 or human CRF-2alpha (Chen et al, Proc Natl Acad Sci USA 90, 89...

US Patent US8835444 (2014)


BindingDB Entry DOI: 10.7270/Q28K77ST
More data for this
Ligand-Target Pair