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BDBM131874 US8835444, 4.5

SMILES: Cc1cc(CO)nn1C[C@H]1CC[C@@H](CC1)NC(=O)c1cc(Cl)cnc1C

InChI Key: InChIKey=TWBGPAWOFRHVHU-KOMQPUFPSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 131874   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM131874
PNG
(US8835444, 4.5)
Show SMILES Cc1cc(CO)nn1C[C@H]1CC[C@@H](CC1)NC(=O)c1cc(Cl)cnc1C |r,wU:9.9,wD:12.16,(3,-.38,;4.34,.38,;5.8,-.09,;6.71,1.15,;8.25,1.15,;9.02,-.18,;5.8,2.4,;4.32,1.93,;2.99,2.69,;1.65,1.93,;1.65,.38,;.32,-.38,;-1.01,.38,;-1.01,1.93,;.32,2.69,;-2.35,-.38,;-3.68,.38,;-3.68,1.93,;-5.02,-.38,;-6.35,.38,;-7.68,-.38,;-9.02,.38,;-7.68,-1.93,;-6.35,-2.69,;-5.02,-1.93,;-3.68,-2.69,)|
Show InChI InChI=1S/C19H25ClN4O2/c1-12-7-17(11-25)23-24(12)10-14-3-5-16(6-4-14)22-19(26)18-8-15(20)9-21-13(18)2/h7-9,14,16,25H,3-6,10-11H2,1-2H3,(H,22,26)/t14-,16-
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Similars
US Patent
n/an/a 665n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing either the human or rat recombinant CRF-1 or human CRF-2alpha (Chen et al, Proc Natl Acad Sci USA 90, 89...

US Patent US8835444 (2014)


BindingDB Entry DOI: 10.7270/Q28K77ST
More data for this
Ligand-Target Pair