BDBM13220 2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(4-bromo-2,6-dimethylphenyl)-1,3-thiazole-5-carboxamide::BMS-354825 tert-Butoxycarbamate Analog 5d::CHEMBL340322::tert-butyl N-{5-[(4-bromo-2,6-dimethylphenyl)carbamoyl]-4-methyl-1,3-thiazol-2-yl}carbamate

SMILES: Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cc(Br)cc1C

InChI Key: InChIKey=DATBTZXMDPSUJS-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 13220   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM13220 (2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(4-...) Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cc(Br)cc1C Show InChI InChI=1S/C18H22BrN3O3S/c1-9-7-12(19)8-10(2)13(9)21-15(23)14-11(3)20-16(26-14)22-17(24)25-18(4,5)6/h7-8H,1-6H3,(H,21,23)(H,20,22,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	7.0	22
Bristol-Myers Squibb Company					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 49: 6819-32 (2006) Article DOI: 10.1021/jm060727j BindingDB Entry DOI: 10.7270/Q2QN6501
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM13220 (2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(4-...) Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cc(Br)cc1C Show InChI InChI=1S/C18H22BrN3O3S/c1-9-7-12(19)8-10(2)13(9)21-15(23)14-11(3)20-16(26-14)22-17(24)25-18(4,5)6/h7-8H,1-6H3,(H,21,23)(H,20,22,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human p56 Lck tyrosine kinase				Bioorg Med Chem Lett 13: 4007-10 (2003) BindingDB Entry DOI: 10.7270/Q2CC103J
					More data for this Ligand-Target Pair
Tyrosine-protein kinase LCK (Mus musculus)	BDBM13220 (2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(4-...) Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cc(Br)cc1C Show InChI InChI=1S/C18H22BrN3O3S/c1-9-7-12(19)8-10(2)13(9)21-15(23)14-11(3)20-16(26-14)22-17(24)25-18(4,5)6/h7-8H,1-6H3,(H,21,23)(H,20,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of mouse p56 Lck tyrosine kinase				Bioorg Med Chem Lett 13: 4007-10 (2003) BindingDB Entry DOI: 10.7270/Q2CC103J
					More data for this Ligand-Target Pair
Lck (Mus musculus)	BDBM13220 (2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(4-...) Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cc(Br)cc1C Show InChI InChI=1S/C18H22BrN3O3S/c1-9-7-12(19)8-10(2)13(9)21-15(23)14-11(3)20-16(26-14)22-17(24)25-18(4,5)6/h7-8H,1-6H3,(H,21,23)(H,20,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	7.0	22
Bristol-Myers Squibb Company					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 49: 6819-32 (2006) Article DOI: 10.1021/jm060727j BindingDB Entry DOI: 10.7270/Q2QN6501
					More data for this Ligand-Target Pair