BDBM13235 5-N-(2-chloro-6-methylphenyl)-4-methyl-2-N-(thiophene-3-)-1,3-thiazole-2,5-diamido::BMS-354825 2-Amino-4-methyl-thiazole Analog 7i::N-(2-chloro-6-methylphenyl)-4-methyl-2-[(thien-3-ylcarbonyl)amino]-1,3-thiazole-5-carboxamide

SMILES: Cc1nc(NC(=O)c2ccsc2)sc1C(=O)Nc1c(C)cccc1Cl

InChI Key: InChIKey=VRGFWYBOANKTNN-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 13235   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM13235 (5-N-(2-chloro-6-methylphenyl)-4-methyl-2-N-(thioph...) Show SMILES Cc1nc(NC(=O)c2ccsc2)sc1C(=O)Nc1c(C)cccc1Cl Show InChI InChI=1S/C17H14ClN3O2S2/c1-9-4-3-5-12(18)13(9)20-16(23)14-10(2)19-17(25-14)21-15(22)11-6-7-24-8-11/h3-8H,1-2H3,(H,20,23)(H,19,21,22)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...				J Med Chem 49: 6819-32 (2006) Article DOI: 10.1021/jm060727j BindingDB Entry DOI: 10.7270/Q2QN6501
					More data for this Ligand-Target Pair