null

SMILES: Fc1nccc2c3cnc(Nc4ccc(cn4)S(=O)(=O)N4CCNCC4)nc3n(C3CCCC3)c12

InChI Key: InChIKey=UCTSPGHNUJSBEO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 132479   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 4 (Homo sapiens (Human))	BDBM132479 (US8841312, 228) Show SMILES Fc1nccc2c3cnc(Nc4ccc(cn4)S(=O)(=O)N4CCNCC4)nc3n(C3CCCC3)c12 Show InChI InChI=1S/C23H25FN8O2S/c24-21-20-17(7-8-26-21)18-14-28-23(30-22(18)32(20)15-3-1-2-4-15)29-19-6-5-16(13-27-19)35(33,34)31-11-9-25-10-12-31/h5-8,13-15,25H,1-4,9-12H2,(H,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	7.4	37
Amgen Inc. US Patent					Assay Description The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...				US Patent US8841312 (2014) BindingDB Entry DOI: 10.7270/Q2H41Q4H
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6 (Homo sapiens (Human))	BDBM132479 (US8841312, 228) Show SMILES Fc1nccc2c3cnc(Nc4ccc(cn4)S(=O)(=O)N4CCNCC4)nc3n(C3CCCC3)c12 Show InChI InChI=1S/C23H25FN8O2S/c24-21-20-17(7-8-26-21)18-14-28-23(30-22(18)32(20)15-3-1-2-4-15)29-19-6-5-16(13-27-19)35(33,34)31-11-9-25-10-12-31/h5-8,13-15,25H,1-4,9-12H2,(H,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	7.4	37
Amgen Inc. US Patent					Assay Description The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...				US Patent US8841312 (2014) BindingDB Entry DOI: 10.7270/Q2H41Q4H
					More data for this Ligand-Target Pair