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BDBM132503 US8841312, 252

SMILES: CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nn1

InChI Key: InChIKey=DYYOXQSHYDLEFT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 132503   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 4


(Homo sapiens (Human))
BDBM132503
PNG
(US8841312, 252)
Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nn1
Show InChI InChI=1S/C25H30FN9/c1-33(2)16-10-13-34(14-11-16)21-8-7-20(31-32-21)29-25-28-15-19-18-9-12-27-23(26)22(18)35(24(19)30-25)17-5-3-4-6-17/h7-9,12,15-17H,3-6,10-11,13-14H2,1-2H3,(H,28,29,30,31)
PDB
MMDB

NCI pathway
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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (Human))
BDBM132503
PNG
(US8841312, 252)
Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nn1
Show InChI InChI=1S/C25H30FN9/c1-33(2)16-10-13-34(14-11-16)21-8-7-20(31-32-21)29-25-28-15-19-18-9-12-27-23(26)22(18)35(24(19)30-25)17-5-3-4-6-17/h7-9,12,15-17H,3-6,10-11,13-14H2,1-2H3,(H,28,29,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair