null

SMILES: COCCN1CCC(CC1)NC(=O)c1ccc(Nc2ncc(c(Oc3cccc4CN(C)C(=O)c34)n2)C(F)(F)F)c(OC)c1

InChI Key: InChIKey=WXJDTTGYNLEOLX-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 134189   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM134189 (US8846689, 191) Show SMILES COCCN1CCC(CC1)NC(=O)c1ccc(Nc2ncc(c(Oc3cccc4CN(C)C(=O)c34)n2)C(F)(F)F)c(OC)c1 Show InChI InChI=1S/C30H33F3N6O5/c1-38-17-19-5-4-6-23(25(19)28(38)41)44-27-21(30(31,32)33)16-34-29(37-27)36-22-8-7-18(15-24(22)43-3)26(40)35-20-9-11-39(12-10-20)13-14-42-2/h4-8,15-16,20H,9-14,17H2,1-3H3,(H,35,40)(H,34,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...				US Patent US8846689 (2014) BindingDB Entry DOI: 10.7270/Q2BC3X7Z
					More data for this Ligand-Target Pair