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SMILES: COc1cc(C[C@@H](O)CO)ccc1Nc1ncc(c(Oc2cccc3CN(C)C(=O)c23)n1)C(F)(F)F

InChI Key: InChIKey=WGUZGXYTXNBANE-OAHLLOKOSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 134196   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM134196
PNG
(US8846689, 198)
Show SMILES COc1cc(C[C@@H](O)CO)ccc1Nc1ncc(c(Oc2cccc3CN(C)C(=O)c23)n1)C(F)(F)F |r|
Show InChI InChI=1S/C24H23F3N4O5/c1-31-11-14-4-3-5-18(20(14)22(31)34)36-21-16(24(25,26)27)10-28-23(30-21)29-17-7-6-13(8-15(33)12-32)9-19(17)35-2/h3-7,9-10,15,32-33H,8,11-12H2,1-2H3,(H,28,29,30)/t15-/m1/s1
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Similars
US Patent
n/an/a 1n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...

US Patent US8846689 (2014)


BindingDB Entry DOI: 10.7270/Q2BC3X7Z
More data for this
Ligand-Target Pair