BDBM134226 US8846673, 96

SMILES: CS(=O)(=O)Nc1ccc(cc1)-c1ncc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c12

InChI Key: InChIKey=RMNHYPZVNFTHCB-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 134226   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM134226 (US8846673, 96) Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ncc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c12 Show InChI InChI=1S/C25H21N5O3S/c1-34(31,32)30-18-11-7-17(8-12-18)23-24-22(25(26)29-28-24)21(15-27-23)16-9-13-20(14-10-16)33-19-5-3-2-4-6-19/h2-15,30H,1H3,(H3,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	280	n/a	n/a	n/a	n/a	7.4	0
Bristol-Myers Squibb Company US Patent					Assay Description To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...				US Patent US8846673 (2014) BindingDB Entry DOI: 10.7270/Q26M35HM
					More data for this Ligand-Target Pair