BDBM134241 US8846673, 223

SMILES: Nc1n[nH]c2cc(nc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc(cc1)-c1nnn[nH]1

InChI Key: InChIKey=VOQVWFPOYLGTJD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 134241   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM134241 (US8846673, 223) Show SMILES Nc1n[nH]c2cc(nc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc(cc1)-c1nnn[nH]1 Show InChI InChI=1S/C25H18N8O/c26-24-22-21(28-29-24)14-20(15-6-8-17(9-7-15)25-30-32-33-31-25)27-23(22)16-10-12-19(13-11-16)34-18-4-2-1-3-5-18/h1-14H,(H3,26,28,29)(H,30,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	0
Bristol-Myers Squibb Company US Patent					Assay Description To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...				US Patent US8846673 (2014) BindingDB Entry DOI: 10.7270/Q26M35HM
					More data for this Ligand-Target Pair