BDBM134243 US8846673, 236

SMILES: Nc1n[nH]c2cc(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)Nc1ccccc1

InChI Key:

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 134243   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM134243 (US8846673, 236) Show SMILES Nc1n[nH]c2cc(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)Nc1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	0
Bristol-Myers Squibb Company US Patent					Assay Description To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...				US Patent US8846673 (2014) BindingDB Entry DOI: 10.7270/Q26M35HM
					More data for this Ligand-Target Pair