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SMILES: CO[C@@H]1CCN(CC1(C)C)c1nc(nc2CCN(Cc12)c1cc(ccc1C)C(F)(F)F)-c1c(C)cccc1C

InChI Key: InChIKey=MIKVOBAUKFGHEM-AREMUKBSSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 134515   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
C5a anaphylatoxin chemotactic receptor 1


(Homo sapiens (Human))		BDBM134515
PNG
(US8846656, 21-AB)
Show SMILES CO[C@@H]1CCN(CC1(C)C)c1nc(nc2CCN(Cc12)c1cc(ccc1C)C(F)(F)F)-c1c(C)cccc1C |r|
Show InChI InChI=1S/C31H37F3N4O/c1-19-10-11-22(31(32,33)34)16-25(19)37-14-12-24-23(17-37)29(38-15-13-26(39-6)30(4,5)18-38)36-28(35-24)27-20(2)8-7-9-21(27)3/h7-11,16,26H,12-15,17-18H2,1-6H3/t26-/m1/s1
PDB

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antibodypedia
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UniChem

Similars
US Patent
n/an/a 4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...

US Patent US8846656 (2014)


BindingDB Entry DOI: 10.7270/Q2JW8CKR
More data for this
Ligand-Target Pair