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SMILES: CC(C)n1cc(C(=O)c2cncc(NC(=O)c3c[nH]c4ncc(C)cc34)c2)c2cncnc12

InChI Key: InChIKey=HSIBFHYDRWLHLF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 134931   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM134931
PNG
(US8846698, 412)
Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)c3c[nH]c4ncc(C)cc34)c2)c2cncnc12
Show InChI InChI=1S/C24H21N7O2/c1-13(2)31-11-20(18-9-26-12-29-23(18)31)21(32)15-5-16(8-25-7-15)30-24(33)19-10-28-22-17(19)4-14(3)6-27-22/h4-13H,1-3H3,(H,27,28)(H,30,33)
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Similars
US Patent
n/an/a 5.18n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...

US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair