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SMILES: OCC1(CC1)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cc3)C(F)(F)F)c2)c2cncnc12

InChI Key: InChIKey=WFOLIXTXHLWCEG-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 135041   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM135041
PNG
(US8846698, 524)
Show SMILES OCC1(CC1)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cc3)C(F)(F)F)c2)c2cncnc12
Show InChI InChI=1S/C25H20F3N5O3/c26-25(27,28)17-3-1-15(2-4-17)7-21(35)32-18-8-16(9-29-10-18)22(36)20-12-33(24(13-34)5-6-24)23-19(20)11-30-14-31-23/h1-4,8-12,14,34H,5-7,13H2,(H,32,35)
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Similars
US Patent
n/an/a 4.53n/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...

US Patent US8846698 (2014)


BindingDB Entry DOI: 10.7270/Q2F47MTW
More data for this
Ligand-Target Pair