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BDBM135188 US8846657, 3.81

SMILES: C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)N2CCCC2c2nccs2)CC1

InChI Key:

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 135188   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MDM2-MDMX


(Homo sapiens (Human))		BDBM135188
PNG
(US8846657, 3.81)
Show SMILES C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)N2CCCC2c2nccs2)CC1 |r,wU:1.0,wD:4.4,(7.09,-3.86,;5.6,-3.46,;4.52,-4.55,;3.03,-4.15,;2.63,-2.66,;1.14,-2.27,;.74,-.78,;1.65,.47,;.74,1.71,;-.72,1.24,;-2.05,2.01,;-3.39,1.24,;-3.39,-.3,;-2.05,-1.07,;-2.05,-2.61,;-.72,-3.38,;-.72,-4.92,;-2.05,-5.69,;-3.39,-4.92,;-4.72,-5.69,;-3.39,-3.38,;-.72,-.3,;-4.72,2.01,;-6.19,1.53,;-7.09,2.78,;-6.19,4.02,;-6.96,5.36,;-4.72,3.55,;3.19,.47,;4.09,-.78,;5.56,-.3,;5.56,1.24,;4.09,1.71,;3.7,3.2,;2.23,3.68,;2.23,5.22,;3.7,5.69,;4.6,4.45,;3.72,-1.58,;5.21,-1.97,)|
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Similars
US Patent
n/an/a<1n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...

US Patent US8846657 (2014)


BindingDB Entry DOI: 10.7270/Q29C6W3K
More data for this
Ligand-Target Pair