BDBM135306 US8846657, 5.9

SMILES: C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)N2[C@H](C)CN(C[C@H]2C)C(=O)C2CCC2)CC1

InChI Key:

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 135306   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM135306 (US8846657, 5.9) Show SMILES C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)N2[C@H](C)CN(C[C@H]2C)C(=O)C2CCC2)CC1 |r,wU:1.0,34.39,wD:4.4,29.33,(5.61,-3.69,;4.12,-3.29,;3.03,-4.38,;1.54,-3.98,;1.14,-2.5,;-.34,-2.1,;-.74,-.61,;.16,.64,;-.74,1.88,;-2.21,1.41,;-3.54,2.18,;-4.88,1.41,;-4.88,-.13,;-3.54,-.9,;-3.54,-2.44,;-2.21,-3.21,;-2.21,-4.75,;-3.54,-5.52,;-4.88,-4.75,;-6.21,-5.52,;-4.88,-3.21,;-2.21,-.13,;-6.21,2.18,;-7.67,1.7,;-8.58,2.95,;-7.67,4.19,;-8.44,5.52,;-6.21,3.72,;1.7,.64,;2.47,1.97,;1.7,3.3,;4.01,1.97,;4.78,.64,;4.01,-.7,;2.47,-.7,;.93,-.7,;6.32,.64,;7.09,-.7,;7.09,1.97,;8.58,2.37,;8.18,3.86,;6.69,3.46,;2.23,-1.41,;3.72,-1.81,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...				US Patent US8962611 (2015) BindingDB Entry DOI: 10.7270/Q28G8JDZ
					More data for this Ligand-Target Pair
MDM2-MDMX (Homo sapiens (Human))	BDBM135306 (US8846657, 5.9) Show SMILES C[C@H]1CC[C@H](Cn2c(nc3cc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)N2[C@H](C)CN(C[C@H]2C)C(=O)C2CCC2)CC1 |r,wU:1.0,34.39,wD:4.4,29.33,(5.61,-3.69,;4.12,-3.29,;3.03,-4.38,;1.54,-3.98,;1.14,-2.5,;-.34,-2.1,;-.74,-.61,;.16,.64,;-.74,1.88,;-2.21,1.41,;-3.54,2.18,;-4.88,1.41,;-4.88,-.13,;-3.54,-.9,;-3.54,-2.44,;-2.21,-3.21,;-2.21,-4.75,;-3.54,-5.52,;-4.88,-4.75,;-6.21,-5.52,;-4.88,-3.21,;-2.21,-.13,;-6.21,2.18,;-7.67,1.7,;-8.58,2.95,;-7.67,4.19,;-8.44,5.52,;-6.21,3.72,;1.7,.64,;2.47,1.97,;1.7,3.3,;4.01,1.97,;4.78,.64,;4.01,-.7,;2.47,-.7,;.93,-.7,;6.32,.64,;7.09,-.7,;7.09,1.97,;8.58,2.37,;8.18,3.86,;6.69,3.46,;2.23,-1.41,;3.72,-1.81,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 wi...				US Patent US8846657 (2014) BindingDB Entry DOI: 10.7270/Q29C6W3K
					More data for this Ligand-Target Pair