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SMILES: Cc1c(sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12)C(N)=O

InChI Key: InChIKey=AKEQBQFIVLCUPH-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 136194   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM136194
PNG
(US8853193, 23-3)
Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12)C(N)=O
Show InChI InChI=1S/C17H15F3N4O2S/c1-8-13-16(22-7-23-17(13)27-14(8)15(21)25)24-11-3-2-9(20)4-12(11)26-10(5-18)6-19/h2-4,7,10H,5-6H2,1H3,(H2,21,25)(H,22,23,24)
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Similars
US Patent
n/an/a 4n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...

US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair