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SMILES: CN(C)CCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c2c1C

InChI Key: InChIKey=KYCNWPBVMKMXQE-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 136198   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM136198
PNG
(US8853193, 23-7)
Show SMILES CN(C)CCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c2c1C
Show InChI InChI=1S/C21H24F3N5O2S/c1-12-17-19(28-15-5-4-13(24)8-16(15)31-14(9-22)10-23)26-11-27-21(17)32-18(12)20(30)25-6-7-29(2)3/h4-5,8,11,14H,6-7,9-10H2,1-3H3,(H,25,30)(H,26,27,28)
PDB
MMDB

KEGG

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PC sid
UniChem

Similars
US Patent
n/an/a 17n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...

US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair