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SMILES: Cc1c(sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12)C(=O)NCCO

InChI Key: InChIKey=BRAXAQCMBMIKJL-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 136199   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))		BDBM136199
PNG
(US8853193, 23-8)
Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12)C(=O)NCCO
Show InChI InChI=1S/C19H19F3N4O3S/c1-10-15-17(24-9-25-19(15)30-16(10)18(28)23-4-5-27)26-13-3-2-11(22)6-14(13)29-12(7-20)8-21/h2-3,6,9,12,27H,4-5,7-8H2,1H3,(H,23,28)(H,24,25,26)
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MMDB

KEGG

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KEGG
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 8n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...

US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair